HEART FAILURE: Angiotensin receptor blockers for chronic heart failure and acute myocardial infarction

ACE inhibitors vs. angiotensin II receptor blockers in acute myocardial infarction and heart failure.

Angiotensin receptor blockers and aldosterone antagonists in chronic heart failure.

Prognosis in congestive heart failure is directly linked to neurohormonal activation. Angiotensin II through the activation of the renin angiotensin aldosterone system has been the principal focus therapy over the last 2 decades. New agents that target selective blockade of the angiotensin II receptor have been introduced in clinical trials for the treatment of heart failure. Aldosterone has be...

Are angiotensin II receptor blockers indicated in chronic heart failure?

Chronic heart failure is one of the most serious cardiac problems encountered in clinical practice. Modulation of the renin angiotensin system is a key element in the treatment of this syndrome. There is overwhelming evidence in favour of the benefit of angiotensin converting enzyme (ACE) inhibitors on morbidity and mortality in mild to severe heart failure and in heart failure or left ventricu...

Aldosterone Receptor Antagonist and Heart Failure Following Acute Myocardial Infarction

The presence of heart failure or LV systolic dysfunction in the setting of acute myocardial infarction is associated with poor prognosis. Aldosterone is an important downstream mediator of the renin-angiotensin-aldosterone system which, in the post-acute myocardial infarction setting, promotes myocardial collagen deposition, myocardial fibrosis, apoptosis, endothelial dysfunction, ventricular r...

Acute heart failure after myocardial infarction.

We compared two groups of patients after acute myocardial infarction. First group was treated with fibrinolytics and they were hospitalized within six hours from the beginning of the first chest-symptoms, and second group that did not come within optimal time was treated with anticoagulants only. The patients were classified according to Killip-classification, shock-index and TIMI-risk-score af...